Introduction to LC-MS Data Interpretation

Thursday, July 16, 2026
8am PDT | 11am EDT | 4pm BST | 5pm CEST

Following on from our Introduction to LC-MS Fragmentation webcast, this session explores how mass spectrometric data are interpreted to support the structural elucidation of unknown related substances.
Using a detailed worked example, we demonstrate how chromatographic, mass spectral, and fragmentation data are combined to build evidence for proposed chemical structures. Attendees will gain an understanding of the systematic approach used to evaluate analytical data and develop structural hypotheses for unknown impurities and related substances.

Topics include:
•    Reviewing key LC-MS fragmentation principles
•    Interpreting molecular ion and isotopic pattern information
•    Using fragmentation data to support structural assignments
•    Developing and evaluating structural hypotheses
•    Applying a systematic workflow to unknown related substances
•    Worked case study in LC-MS data interpretation

This webcast provides a practical introduction to the thought process and techniques used in LC-MS-based structural elucidation.

 

Speakers

 

Colin Towers (Senior Technical Support Chemist, Crawford Scientific)


After completing a degree in pharmacy, Colin pursued a career in analytical chemistry. Following three years performing routine testing and three years instrument maintenance and calibration, he moved into a role as a method development and validation specialist in contract research. Gaining 11 years’ experience in developing methods for HPLC, LC-MS, GC, GC-MS and SPE in a high throughput commercial environment, this was supplemented by three years lecturing in forensic analytical toxicology and a further three years working as a community pharmacist. Colin has now been with Crawford Scientific since 2011 as a technical specialist, consultant, and trainer.

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